Application of Centrifuge in Pharmaceutical-Industry

Requirements for equipment:

u The design, selection and installation of equipment shall conform to the requirements of drug production and be easy to clean, disinfect or sterilize, Easy to operate&repair. Maintain, prevent errors or reduce pollution.

u The surface of equipment in direct contact with drugs should be smooth, free of dead angles, easy to clean or disinfect, corrosion resistant, No chemical changes with drugs or adsorption of drugs.

u Lubricant, coolant, etc. used for equipment shall not cause contamination of medicines or containers. The pipe shall be designed and installed in such a way as to avoid dead-angle and blind pipes.

u Instruments, gauges,  weighing devices, ete., used for production and inspection, whose scope of application and precision shall conforrn to the requirements of production and inspection, and shall have clearly qualified marks.

u Production equipment should have clear Status sign, and regular repair, maintenance and verification. Installation, repair and maintenance of equipment must affect the quality of the product.

u For instruments and instruments with special requirements, they should be placed in a special instrument room with facilities to prevent static electricity, vibration, moisture or other external factors.

Centrifugal Process Test and Verification

Filtration and settlement speed are the main basis for selection. the separation process is determined according to the physical and chemical properties of solid-Iiquid mixture is analyze. and the necessary technical and economic analysis( product quality, yield，energy consumption，production capacity, operation safety) is carried out. and suitable separation equipment is selected. the necessary parameters were optimized to achieve higher yield，Iower energy consumption and consumption under the premise of satisfying the technical requirements of separation process.

we should choose the proper filtration medium，discharge method and washing method etc in the filtration test. we should not use settling method to separate solid and liquid phase when the density difference between solid and liquid phase is very small. Either by appropriate process to increase the density difference, or through the centrifugal force to increase its separation power.

Filtration and separation is an experimental technique. For specific materials and working conditions. the data of filtration and separation are obtained through accumulated experience and necessary tests. and the suitable separation equipment and process are selected to achieve the desired purpose.